一、團(tuán)隊(duì)名稱

谷物功能因子研發(fā)與質(zhì)量安全控制團(tuán)隊(duì)

二、團(tuán)隊(duì)介紹

團(tuán)隊(duì)研究方向：功能食品、食品安全

主要研究內(nèi)容包括：食品原料中功能因子分離提取、結(jié)構(gòu)鑒定、功能性評價(jià)研究以及糧油食品質(zhì)量安全控制研究。基于胞外囊泡的食品功能因子遞送體系研發(fā)及其調(diào)控腸腦相關(guān)炎癥的作用機(jī)制。食品和環(huán)境污染物的毒性評價(jià)，食品中活性因子的功能性評價(jià)，探討功能性因子對污染物毒性的緩解和保護(hù)機(jī)制。

團(tuán)隊(duì)近五年承擔(dān)國家科技部重點(diǎn)研發(fā)計(jì)劃子課題1項(xiàng)、國家自然科學(xué)基金項(xiàng)目1項(xiàng)、江蘇省高校自然科學(xué)重大項(xiàng)目1項(xiàng)，江蘇省農(nóng)業(yè)科技自主創(chuàng)新資金項(xiàng)目1項(xiàng)，江蘇省高等教育教改課題1項(xiàng)；中國博士后科學(xué)基金面上資助項(xiàng)目1項(xiàng)。發(fā)表SCI文章50余篇，授權(quán)發(fā)明專利3項(xiàng)。劉琴教授兼任江蘇省分析測試協(xié)會(huì)，色譜質(zhì)譜分會(huì)委員會(huì)委員/江蘇省分析測試協(xié)會(huì)高校分會(huì)委員（理事）/江蘇省化學(xué)化工學(xué)會(huì)分析化學(xué)專業(yè)委員會(huì)委員。朱珍珠博士入選全國首批“博士后創(chuàng)新人才支持計(jì)劃”及江蘇省科技鎮(zhèn)長團(tuán)成員；楊倩博士入選2022年江蘇省科技副總項(xiàng)目。劉琴教授獲江蘇省教學(xué)成果獎(jiǎng)（排名第四），楊倩博士獲南京財(cái)經(jīng)大學(xué)教師教學(xué)公開賽二等獎(jiǎng)，被評為“學(xué)生最喜愛的老師”。

三、科研成果

1代表性的科研項(xiàng)目

1）國家科技部重點(diǎn)研發(fā)項(xiàng)目子課題“糧食質(zhì)量安全調(diào)查扦樣規(guī)范研究與典型區(qū)域污染物數(shù)據(jù)庫構(gòu)建（2017YFC1600601）”

2）江蘇省科技農(nóng)業(yè)自主創(chuàng)新資金項(xiàng)目“糧食（小麥）產(chǎn)品質(zhì)量安全主要危害因子識(shí)別、風(fēng)險(xiǎn)評估與防控技術(shù)（CX(17)1003）”

3）江蘇省高校自然科學(xué)研究重大項(xiàng)目“谷物多酚及其功能性評價(jià)（11KJA550001）”

4）國家自然科學(xué)基金項(xiàng)目“線粒體靶向性鉑類配合物干預(yù)腫瘤代謝機(jī)制的研究（31700714）”

5）企業(yè)委托項(xiàng)目“場地土壤有毒有害污染物健康風(fēng)險(xiǎn)識(shí)別與評估”，“中大石英科技有限公司廢水生物綜合毒性評價(jià)項(xiàng)目”，“疏水性絮凝劑的制備工藝和性能測試服務(wù)”。

2代表性論文

1）Zhu, Zhenzhu; Yang, Lipin; Li, Zhong; Liu, Qin^*. Cyanidin-3-O-glucoside, cyanidin and oxidation products of cyanidin protect neuronal function through alleviating inflammation and oxidative damage. Journal of Food Science, 2022, 87, 2159-2172. (IF 3.377)

2）Yang, Qian; Zhu, Zhenzhu; Liu, Qin^*; Chen, Lihong^*. Adverse effects of bisphenol B exposure on the thyroid and nervous system in early life stages of zebrafish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2021, 250, 109167. (IF 3.228)

3）Gan, Yuanruo; Fu, Yong; Yang, Lipin; Chen, Jiangning; Lei, Hong; Liu, Qin ^*. Cyanidin-3-O-Glucoside and cyanidin protect against intestinal barrier damage and 2,4,6-trinitrobenzenesulfonic acid-induced colitis. Journal of Medicinal Food, 2020, 23, 90-99. (IF 2.542)

4）Zhu, Zhenzhu; Yang, Tao; Zhang, Lei; Liu, Lulu; Yin, Enmao; Zhang, Changli; Guo, Zijian; Xu, Chen; Wang, Xiaoyong^*. Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative. European Journal of Medicinal Chemistry, 2019, 168, 330-339. (IF 4.833)

5）Yang, Tao^?; Zhu, Zhenzhu^?; Yin, Enmao; Wang, Yanqing; Zhang, Changli; Yuan, Hao; Zhang, Hongmei; Jin, Suxing; Guo, Zijian; Wang, Xiaoyong^*. Alleviation of symptoms in Alzheimer's disease by diminishing Aβ-neurotoxicity and neuroinflammation. Chemical Science, 2019, 10, 10149-10158. (IF 9.658)

6）Wang, Jinzhuan; Wang, Kun; Zhu Zhenzhu^*; He, Yafeng; Zhang, Changli; Guo, Zijian^*; Wang, Xiaoyong^*. Inhibition of metal-induced amyloid β-peptide aggregation by blood-brain barrier permeable silica-cyclen nanochelator. RSC Advances, 2019, 9, 14126-14131. (IF 3.049)

7）Zhu, Zhenzhu; Wang, Zenghui; Zhang, Changli; Wang, Yanjun; Zhang, Hongmei; Gan, Zhenji; Guo, Zijian^*; Wang, Xiaoyong^*. Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism. Chemical Science, 2019, 10, 3089-3095. (IF 9.658)

8）Jin, Suxing; Hao, Yigang; Zhu, Zhenzhu^*; Muhammad, Nafees; Zhang, Zhenqin; Wang, Kun; Guo,Yan; Guo, Zijian; Wang, Xiaoyong^*. Impact of mitochondrion-targeting group on the reactivity and cytostatic pathway of platinum(IV) complexes. Inorganic Chemistry, 2018, 57, 11135-11145. (IF 4.850)

9）Yang, Qian; Yang, Xianhai; Liu, Jining^*; Chen, yingwen^*; Shen, shubao. Effects of exposure to BPF on development and sexual differentiation during early life stages of zebrafish (Danio rerio). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2018, 210, 44-56. (IF 3.228)

10）Zhang, Weina; Zhu, Yuanyuan; Liu, Qingqing; Bao, Jinsong^*; Liu, Qin^*. Identification and quantification of polyphenols in hull, bran and endosperm of common buckwheat (Fagopyrum esculentum) seeds, Journal of Functional Foods, 2017, 38, 363-369. (IF 5.223)

11）Yang, Qian; Yang, Xianhai; Liu, Jining^*; Ren, wenjuan; Chen, yingwen^*; Shen, shubao. Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish. Environmental Science & Pollution Research, 2017, 24(26), 1-12. (IF 5.190)

12）Yang, Qian; Yang, Xianhai; Liu, Jining^*; Ren, wenjuan; Chen, yingwen^*; Shen, shubao. Exposure to bisphenol b disrupts steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish. Water Air Soil Pollut, 2017, 228, 112. (IF 2.984)

中文期刊論文：

[1]廖柳月，朱珍珠^*，楊倩，劉琴．大蒜胞外囊泡活性成分解析及其緩解小鼠結(jié)腸炎作用[J]．食品科學(xué)，2022，網(wǎng)絡(luò)首發(fā)（2022.6.13），https://kns.cnki.net/kcms/detail/11.2206.TS.20220613.1016.038.html.

[2]侯佳麗, 朱珍珠, 謝旻浩, 楊倩, 劉琴^*. 可溶性青梅果膠的表征及其對脂多糖誘導(dǎo)的RAW246.7巨噬細(xì)胞炎癥的抑制作用[J].食品工業(yè)科技，2022， 網(wǎng)絡(luò)首發(fā) (2022.4.19). DOI:10.13386/j.issn1002-0306.2022010013.

[3]朱珍珠^*，江睿，廖柳月，張琳曼，謝丁宇，張婧藝. 植物胞外囊泡的結(jié)構(gòu)、生物活性及其在食藥遞送方面的應(yīng)用[J].食品工業(yè)科技, 2022, 網(wǎng)絡(luò)首發(fā)（2022.3.16）. DOI:10.13386/j.issn1002-0306. 2021110217

[4]楊倩,劉建梅,丁潔,陳麗紅^*.雙酚B對斑馬魚性別分化的影響及作用機(jī)制[J].生態(tài)毒理學(xué)報(bào),2021,16(04):151-159.

[5]楊倩,劉建梅,丁潔,陳麗紅^*.雙酚F對斑馬魚早期生命階段內(nèi)分泌干擾效應(yīng)研究[J].生態(tài)毒理學(xué)報(bào),2021,16(03):166-178.

[6]楊麗嬪,楊倩,王黎麗,周瑞敏,高成成,劉琴^*.鐵棍山藥黏液復(fù)合乳液保鮮鮮切馬鈴薯研究[J].食品與發(fā)酵工業(yè),2021,47(08):46-53.

[7]楊麗嬪，朱珍珠，雷紅，劉琴^*. 花青素對神經(jīng)退行性疾病保護(hù)作用的研究進(jìn)展[J].中國食物與營養(yǎng)，2021, 27(2): 40-45.

[8]熊超平，馬緩，朱恩俊，徐煒楓，劉琴^*. 8種農(nóng)藥殘留在小麥模擬儲(chǔ)藏過程中的降解動(dòng)力學(xué)研究[J].中國糧油學(xué)報(bào), 2020, 35(11): 139-146.

3代表性專利

1）劉琴;劉慶慶;張楚陽;一種從薰衣草花茶中分離純化多酚物質(zhì)的方法,專利號,ZL201710951797.7

2）劉琴;張薇娜;劉慶慶;張珂嘉;一種從甜蕎殼中提取分離黃酮單體物質(zhì)的方法,專利號，ZL201610316090.4

3）劉琴;牛文慧;張薇娜;胡秋輝;一種花青素脂質(zhì)體的制備方法,專利號, ZL201310413928.8

四、研究生畢業(yè)去向

1.攻讀博士學(xué)位：推薦到江南大學(xué)、南京農(nóng)業(yè)大學(xué)等單位攻讀博士學(xué)位。

2.企事業(yè)單位：推薦到益海嘉里、藝康集團(tuán)等企業(yè)和食藥監(jiān)局等檢測單位。

3.報(bào)考公務(wù)員：報(bào)考各級政府部門公務(wù)員。

五、聯(lián)系方式

團(tuán)隊(duì)負(fù)責(zé)人：劉琴

聯(lián)系人： 劉琴

郵箱：qinliu@ nufe.edu.cn